Acliz 50mg Tablet

Uses of Acliz 50mg Tablet

Travel sickness (motion sickness) and Vertigo (a spinning sensation or dizziness).

How does Acliz 50mg Tablet work?

Acliz 50mg Tablet contains Meclizine, a sedating antihistamine medication. It blocks histamine's effects in your brain to reduce symptoms of travel sickness (motion sickness). It also acts as a calcium channel blocker. This helps improve blood flow in the inner ear and reduces symptoms caused by vertigo.

Side Effects of Acliz 50mg Tablet

• Drowsiness
• Fatigue
• Dry mouth
• Constipation
• Stomach upset
• Blurred vision

Quick Suggestions:

Meclizine can increase the effects of other CNS depressants (alcohol, barbiturates) medicine.

• If you are using Meclizine for motion sickness, it should be taken an hour before your travel.
• Avoid consuming alcohol when taking the Meclizine, as it may cause excessive sleepiness or drowsiness.

Indication

Acliz 50mg Tablet is an antihistamine, used to treat motion sickness, especially to prevent and treat symptoms such as abdominal pain, dizziness, nausea, vomiting, headaches, etc. It is also used for the treatment of vertigo (dizziness or fainting), a condition associated with the disease of the inner ear. This medicine is not recommended for use in children less than 12 years of age.

Pharmacology

Meclizine has antiemetic, anticholinergic, and antihistamine properties. Reduces the sensitivity of the labyrinth device. This effect may be mediated by nerve pathways from the chemoreceptor activation zone (CTZ) to the center of emesis (VC), peripheral nerve pathways, VC, or other CNS centers. Meclizine has an onset time of 30 to 60 minutes, depending on the dose, its duration of action is 12 to 24 hours.

Dosage & Administration of Acliz 50mg Tablet

For Acliz 50mg Tablet, the recommended dosages for different indications are as follows:

1. Nausea and vomiting:

• Adults and children over 12 years: 25-50 mg once daily.

1. Motion sickness:

• Adults and children over 12 years: Take an initial dose of 25-50 mg, 1 hour prior to travel. Repeat the dose every 24 hours if necessary.
• Children (age 6-12 years): 12.5 mg once daily.
• Children (age 2-6 years): 6.25 mg once daily.

1. Vertigo:

• Adults: 25-100 mg daily, divided into multiple doses.

1. Radiotherapy-induced nausea and vomiting:

• Adults: 50 mg two to twelve hours before radiotherapy.

1. Emergency contraception:

• Adults: 25-50 mg, 1 hour before the first dose of emergency contraception (ECP). Repeat if needed within 24 hours.

Please note the following:

Use in children: Clinical studies to establish the safety and efficacy of Acliz 50mg Tablet in children have not been conducted. Therefore, the use of this medication in children should be determined by a physician.

Use in the elderly: There is no specific information available regarding the use of Acliz 50mg Tablet in the elderly. However, older individuals may be more sensitive to the anticholinergic effects of the medication.

It's important to follow the prescribed dosage and instructions provided by your doctor. If you have any concerns or questions about the appropriate dosage for your specific condition, it is best to consult with your healthcare provider.

Interaction

Here is a list of some common medications and drug classes that may interact with Acliz 50mg Tablet:

1. Alzheimer's disease medications:

• Donepezil
• Galantamine

1. Anticholinergic medications:

• Benztropine
• Scopolamine

1. Antipsychotics:

• Chlorpromazine
• Clozapine
• Fluphenazine
• Thioridazine
• Risperidone
• Trazodone

1. Pain relievers:

• Acetaminophen
• Aspirin
• Ibuprofen
• Codeine
• Hydrocodone
• Oxycodone

1. Diuretic:

• Furosemide

1. Muscle relaxants:

• Cyclobenzaprine
• Orphenadrine
• Baclofen
• Methocarbamol

1. Sedative-hypnotics:

• Zolpidem
• Zaleplon
• Eszopiclone
• Temazepam
• Triazolam
• Estazolam
• Flurazepam
• Suvorexant
• Doxepin

1. Antihistamines:

• Clemastine
• Carbinoxamine
• Diphenhydramine
• Hydroxyzine

It is important to note that this is not an exhaustive list, and there may be other medications that can interact with Acliz 50mg Tablet. It is always recommended to inform your doctor or healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, and any herbal supplements, to avoid potential drug interactions.

Regarding drug-food interactions, Acliz 50mg Tablet may interact with alcohol and increase drowsiness.

Additionally, Acliz 50mg Tablet may have interactions in patients with certain medical conditions such as glaucoma (increased eye pressure), kidney or liver problems, urinary tract blockage, an enlarged prostate, and asthma.

It is crucial to consult with your doctor or pharmacist before starting or stopping any medication to ensure safe and appropriate use. They will be able to provide you with personalized advice based on your specific situation and medical history.

Contraindications

Patients allergic to meclizine or any of its excipients should not use meclizine.

Pregnancy & Lactation

Meclizine, the active ingredient in Acliz 50mg Tablet, does not typically show a risk of birth defects or abnormalities when used during pregnancy. However, it is always important to consult with a healthcare professional before taking any medication during pregnancy to ensure the safety and appropriateness of its use based on individual circumstances.

Regarding breastfeeding, meclizine is excreted in breast milk, but it is generally considered safe to use while breastfeeding as it does not typically cause harm to nursing babies. However, it is still recommended to consult with a healthcare professional before using meclizine or any other medication while breastfeeding to ensure its safety for both the mother and the baby.

It's important to note that individual situations may vary, and the guidance of a healthcare professional is essential for making informed decisions about medication use during pregnancy and breastfeeding.

Precautions & Warnings

Allergy: Do not take Acliz 50mg Tablet if you are allergic to Acliz 50mg Tablet or any of its ingredients.

Medications and Herbal Products: Inform your doctor about all other medications and herbal products you are taking or have been taking, as there may be potential interactions.

Urinary Bladder Problems: If you have a problem emptying the urinary bladder, it is important to inform your doctor before starting Acliz 50mg Tablet.

Glaucoma: Acliz 50mg Tablet should be used with caution in individuals with glaucoma (increased eye pressure). Inform your doctor if you have this condition.

Liver or Kidney Disease: Inform your doctor if you have liver or kidney disease, as the use of Acliz 50mg Tablet may require special precautions or dosage adjustments.

Asthma: Acliz 50mg Tablet should be used with caution in individuals with asthma. Inform your doctor if you have this condition.

Enlarged Prostate: If you have an enlarged prostate, it is important to inform your doctor before taking Acliz 50mg Tablet.

Alcohol: Avoid consuming alcohol while taking Acliz 50mg Tablet, as it may increase drowsiness and intensify the sedative effects of the medication.

Pregnancy and Breastfeeding: It is recommended not to take Acliz 50mg Tablet if you are pregnant or planning to become pregnant. Similarly, if you are breastfeeding, it is advisable to avoid Acliz 50mg Tablet. Consult with your doctor for appropriate alternatives or guidance.

Yellowing of Skin and Pale Urine: If you experience yellowing of the skin and pale urine, consult your doctor immediately, as it may indicate a serious condition that requires medical attention.

Storage Conditions

Store in a cool & dry place and away from children.